Sajiv K Nair: search on Z-Library

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1

Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility

James A. Nieman, Sajiv K. Nair, Steven E. Heasley, Brenda L. Schultz, Herbert M. Zerth, Richard A. Nugent, Ke Chen, Kevin J. Stephanski, Todd A. Hopkins, Mary L. Knechtel, Nancee L. Oien, Janet L. Wie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 581 KB

english, 2010

2

Discovery of N -((3 R ,4 R )-4-Fluoro-1-(6-((3-methoxy-1-methyl-1 H -pyrazol-4-yl)amino)-9-methyl-9 H -purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Planken, Simon, Behenna, Douglas C., Nair, Sajiv K., Johnson, Theodore O., Nagata, Asako, Almaden, Chau, Bailey, Simon, Ballard, T. Eric, Bernier, Louise, Cheng, Hengmiao, Cho-Schultz, Sujin, Dalvie,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 2.86 MB

english, 2017

3

Multifaceted SubstrateâLigand Interactions Promote the Copper-Catalyzed Hydroboration of Benzylidenecyclobutanes and Related Compounds

Kang, Taeho, Erbay, TuÄÃ§e G., Xu, Kane L., Gallego, Gary M., Burtea, Alexander, Nair, Sajiv K., Patman, Ryan L., Zhou, Ru, Sutton, Scott C., McAlpine, Indrawan J., Liu, Peng, Engle, Keary M.

Journal:

Year:

2020

File:

PDF, 2.16 MB

2020

4

ChemInform Abstract: An Efficient Gram-Scale Synthesis of (+)-Discodermolide

Sajiv K. Nair, John T. Henri, Gunda I. Georg

Journal:

Year:

2000

File:

PDF, 24 KB

2000

5

ChemInform Abstract: Total Synthesis of Cryptophycin-24 (Arenastatin A) (III) Amenable to Structural Modifications in the C16 Side Chain.

MariJean Eggen, Craig J. Mossman, Suzanne B. Buck, Sajiv K. Nair, Laxminarayan Bhat, Syed M. Ali, Emily A. Reiff, Thomas C. Boge, Gunda I. Georg

Journal:

Year:

2001

Language:

english

File:

PDF, 33 KB

english, 2001

6

ChemInform Abstract: Rapid Entry into the Cryptophycin Core via an Acyl-β-lactam Macrolactonization: Total Synthesis of Cryptophycin-24.

MariJean Eggen, Sajiv K. Nair, Gunda I. Georg

Journal:

Year:

2001

File:

PDF, 31 KB

2001

7

Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine

Jeffrey N. Hemenway, Pekka Jarho, John T. Henri, Sajiv K. Nair, David VanderVelde, Gunda I. Georg, Valentino J. Stella

Journal:

Journal of Pharmaceutical Sciences

Year:

2010

Language:

english

File:

PDF, 229 KB

english, 2010

8

Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells

Oliver E. Hutt, Bollu S. Reddy, Sajiv K. Nair, Emily A. Reiff, John T. Henri, Jack F. Greiner, Ting-Lan Chiu, David G. VanderVelde, Elizabeth A. Amin, Richard H. Himes, Gunda I. Georg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 306 KB

english, 2008

9

Total synthesis and evaluation of 22-(3-azidobenzoyloxy)methyl epothilone C for photoaffinity labeling of β-tubulin

Oliver E. Hutt, Jun Inagaki, Bollu S. Reddy, Sajiv K. Nair, Emily A. Reiff, John T. Henri, Jack F. Greiner, David G. VanderVelde, Ting-Lan Chiu, Elizabeth A. Amin, Richard H. Himes, Gunda I. Georg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 307 KB

english, 2009

10

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275

Michael Siu, Theodore O. Johnson, Yong Wang, Sajiv K. Nair, Wendy D. Taylor, Stephan J. Cripps, Jean J. Matthews, Martin P. Edwards, Thomas A. Pauly, Jacques Ermolieff, Arturo Castro, Natilie A. Hosea

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.42 MB

english, 2009

11

The development and SAR of pyrrolidine carboxamide 11β-HSD1 inhibitors

Hengmiao Cheng, Jacqui Hoffman, Phuong Le, Sajiv K. Nair, Stephan Cripps, Jean Matthews, Christopher Smith, Michele Yang, Stan Kupchinsky, Klaus Dress, Martin Edwards, Bridget Cole, Evan Walters, Chri

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 611 KB

english, 2010

12

Practical syntheses of the C12–C21 epothilone subunit via catalytic asymmetric reductions: Itsuno–Corey oxazaborolidine reduction and asymmetric Noyori hydrogenation

Emily A Reiff, Sajiv K Nair, B.S Narayan Reddy, Jun Inagaki, John T Henri, Jack F Greiner, Gunda I Georg

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 251 KB

english, 2004

13

Novel synthesis of CP-734432, an EP4 agonist, using Sharpless asymmetric dihydroxylation

Sajiv K. Nair, Jean J. Matthews, Stephan J. Cripps, Chunrong Ma, Elena Z. Dovalsantos, Alan W. Grubbs, Neal W. Sach, Wolter ten Hoeve, Han Koster, Erik J. Flahive, Steven P. Tanis, Matt Renner, Jim va

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 456 KB

english, 2010

14

Cycloaromatization of a solvolytically generated ene-yne-allene

Robert F. Cunico, Sajiv K. Nair

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 171 KB

english, 1997

15

Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models

Ganesh Prasanna, Jay Fortner, Cathie Xiang, Eric Zhang, Samantha Carreiro, Scott Anderson, Soisurin Sartnurak, Grace Wu, Hovhannes Gukasyan, Michael Niesman, Sajiv Nair, Eugene Rui, Jennifer Lafontain

Journal:

Experimental Eye Research

Year:

2009

Language:

english

File:

PDF, 375 KB

english, 2009

16

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Strategies to eliminate reactive metabolites

Nair, Sajiv K., Matthews, Jean J., Cripps, Stephan J., Cheng, Hengmiao, Hoffman, Jacqui E., Smith, Christopher, Kupchinsky, Stanley, Siu, Michael, Taylor, Wendy D., Wang, Yong, Johnson, Theodore O., D

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.19 MB

english, 2013

17

Total Synthesis of Cryptophycin-24 (Arenastatin A) Amenable to Structural Modifications in the C16 Side Chain

Eggen, MariJean, Mossman, Craig J., Buck, Suzanne B., Nair, Sajiv K., Bhat, Laxminarayan, Ali, Syed M., Reiff, Emily A., Boge, Thomas C., Georg, Gunda I.

Journal:

Journal of Organic Chemistry

Year:

2000

Language:

english

File:

PDF, 130 KB

english, 2000

18

Total Synthesis and Evaluation of C26-Hydroxyepothilone D Derivatives for Photoaffinity Labeling of β-Tubulin

Reiff, Emily A., Nair, Sajiv K., Henri, John T., Greiner, Jack F., Reddy, Bollu S., Chakrasali, Ramappa, David, Sunil A., Chiu, Ting-Lan, Amin, Elizabeth A., Himes, Richard H., Vander Velde, David G.,

Journal:

Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 4.22 MB

english, 2010

19

Rapid Entry into the Cryptophycin Core via an Acyl-β-lactam Macrolactonization: Total Synthesis of Cryptophycin-24

Eggen, MariJean, Nair, Sajiv K., Georg, Gunda I.

Journal:

Organic Letters

Year:

2001

Language:

english

File:

PDF, 51 KB

english, 2001

20

Synthesis of Cryptophycins via an N -Acyl-β-lactam Macrolactonization

Vidya, Ramdas, Eggen, MariJean, Nair, Sajiv K., Georg, Gunda I., Himes, Richard H.

Journal:

Journal of Organic Chemistry

Year:

2003

Language:

english

File:

PDF, 155 KB

english, 2003

21

An efficient synthesis of α-(trimethylsilyl)allenyl ketones

Cunico, Robert F., Nair, Sajiv K.

Journal:

Synthetic Communications

Year:

1996

Language:

english

File:

PDF, 136 KB

english, 1996

22

Synthesis of Small 3-Fluoro- and 3,3-Difluoropyrrolidines Using Azomethine Ylide Chemistry

McAlpine, Indrawan, Tran-Dubé, Michelle, Wang, Fen, Scales, Stephanie, Matthews, Jean, Collins, Michael R., Nair, Sajiv K., Nguyen, Mary, Bian, Jianwei, Alsina, Luis Martinez, Sun, Jianmin, Zhong, Jia

Journal:

Journal of Organic Chemistry

Year:

2015

Language:

english

File:

PDF, 574 KB

english, 2015

23

Discovery of 1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (PF-06459988), A Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

Cheng, Hengmiao, Nair, Sajiv K, Murray, Brion W., Almaden, Chau, Bailey, Simon, Baxi, Sangita, Behenna, Douglas Carl, Cho-Schultz, Sujin, Dalvie, Deepak, Dinh, Dac M, Edwards, Martin P., Feng, Jun Li,

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 4.17 MB

english, 2016

24

Recent Progress on Third Generation Covalent EGFR Inhibitors

Cheng, Hengmiao, Nair, Sajiv K., Murray, Brion W.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 472 KB

english, 2016

25

ChemInform Abstract: Recent Progress on Third Generation Covalent EGFR Inhibitors

Cheng, Hengmiao, Nair, Sajiv K., Murray, Brion W.

Journal:

Year:

2016

File:

PDF, 16 KB

2016

26

Diastereoselective access to substituted 4-aminopiperidines via a pyridine reduction approach

Murphy, Rebecca A., Chen, Anthony Y., Nair, Sajiv K., Gallego, Gary M., Sach, Neal W., Smith, Graham

Journal:

Tetrahedron Letters

Year:

2016

Language:

english

File:

PDF, 311 KB

english, 2016

27

Waves in shallow water off west coast of India during the onset of summer monsoon

Sanil Kumar, V., Sajiv Philip, C., Balakrishnan Nair, T. N.

Journal:

Annales Geophysicae

Year:

2010

Language:

english

File:

PDF, 2.46 MB

english, 2010

28

Waves in shallow water off west coast of India during the onset of summer monsoon

Sanil Kumar, V., Sajiv Philip, C., Balakrishnan Nair, T. N.

Journal:

Annales Geophysicae

Year:

2010

File:

PDF, 2.46 MB

2010